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Ceritinib for treatment of ALK-rearranged advanced non-small-cell lung cancer.

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Aunque la RHE se prescribe con frecuencia para el alivio de los síntomas, no hay acuerdo sobre el cronograma de fraccionamiento que se debe utilizar.

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Other than the properties of EGFR mutants, the distinct genetic backgrounds in the NSCLC cells (or patients) may also affect the biological responses.

Gefitinib may cause changes in vision.

Laboratories that plan to use these antibodies clinically should validate their use against a valid molecular assay, communicate their clinical performance characteristics (eg, sensitivity, specificity) to their clinicians, and make available referral to another molecular laboratory for molecular testing to exclude mutations in IHC-negative tumors (if not available in-house).

Cisplatin- versus carboplatin-based chemotherapy in first-line treatment of advanced non-small-cell lung cancer: an individual patient data meta-analysis.

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Effects of 17-Allylamino-17-Demethoxygeldanamycin (17-AAG) on Pediatric Acute Lymphoblastic Leukemia (ALL) with Respect to Bcr-Abl Status and Imatinib Mesylate Sensitivity.

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If such concurrent use cannot be avoided, the dose of olaparib should be reduced to 150 mg twice daily.

After the MTD of HCQ is determined, the phase II study will proceed with the combination of 250 mg of Gefitinib and the MTD dose of HCQ.

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The Substrate fits into the active site of the enzyme where the reaction takes place.

Preclinical animal studies in the current anticancer drug development paradigm emphasize the use of rodent efficacy studies () and forgo the use of detailed PK and PD studies.

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Discovery of hybrid Hsp90 inhibitors and their anti-neoplastic effects against gefitinib-resistant non-small cell lung cancer (NSCLC).

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The simultaneous inhibition of these targets therefore reduces tumor vascularization and triggers cancer cell and thus results in tumor shrinkage.

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Management: Limit the eszopiclone dose to 2 mg daily when combined with strong CYP3A4 inhibitors and monitor for increased eszopiclone effects and toxicities (eg, somnolence, drowsiness, CNS depression).

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In instances where there is not enough tissue for EGFR and ALK testing, pathologists should alert the oncologist and include a note in the surgical pathology report to this effect.

Tyrosine kinase inhibitors for non-small-cell lung cancer: finding patients who will be responsive.

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Under regular culture condition, all tested EGFR mutants displayed higher phosphorylation levels at Tyr residues 845, 992, 1068, and 1173 () when compared to that in wild-type EGFR.

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The RET (rearranged during transfection) is a novel fusion gene with various partners including KIF5B (kinesin family member 5B) and others such as CCDC6, NCOA4, and TRIM33 ().

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